Background: To summarize all available evidence from systematic reviews about the impact of stress response in development offirst-episode psychosis (FEP) in schizophrenia.Methods: An overview of systematic reviews of any type of primary studies was performed. An electronic search of fivedatabases was conducted in February 2017 (CDSR, DARE, Embase, MEDLINE and PsychINFO). Quality of included systematicreviews was assessed using the AMSTAR checklist.Results: Eight systematic reviews were included. The main findings of the included reviews point out a possible alteration of thestress response in a subgroup of persons with proneness to psychosis. However, the evidence is limited by the inadequate quality ofstudies, as well as lack of standardization of outcomes and assessment methods.Conclusions: Given the heterogeneity of current results, there is no solid evidence for uniform alterations of stress responsefound in persons with FEP in suggestive of schizophrenia that may serve as a marker of vulnerability to stress and possiblyproneness to psychotic state in response to daily hassles.
展开▼
